> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ADA Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APG01545G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ADA antibody (C-term).
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Molecular Weight |
40764 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
287-314 aa
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Target |
This ADA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human ADA.
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Isotype |
Rabbit Ig
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Symbol |
ADA1
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GeneID |
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UniProt ID |
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Function |
Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion.
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Summary |
This gene encodes an enzyme that catalyzes the hydrolysisof adenosine to inosine. Various mutations have been described forthis gene and have been linked to human diseases. Deficiency inthis enzyme causes a form of severe combined immunodeficiencydisease (SCID), in which there is dysfunction of both B and Tlymphocytes with impaired cellular immunity and decreasedproduction of immunoglobulins, whereas elevated levels of thisenzyme have been associated with congenital hemolytic anemia.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, FC, E
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Dilution |
WB~~1:1000
FC~~1:10~50
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Synonyms |
Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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