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PLCZ1 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
AMR09363G 100 μl / $495

PLCZ1 Antibody (N-term)

Brand

Leading Biology

Catalog Number

AMR09363G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PLCZ1 antibody (N-term).

Molecular Weight

70411 Da

Cellular Localization

Antigen Cellular Localization: Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7} Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

26-54 aa

Target

This PLCZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human PLCZ1.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Synonyms

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase zeta-1, Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1, Testis-development protein NYD-SP27, PLCZ1 (HGNC:19218)

Images

Anti-PLCZ1 Antibody (N-term) at 1:1000 dilution + 293 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 70 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Western blot analysis of PLCZ1 Antibody (N-term) (Cat. AMR09363G) in CEM, 293 cell line and mouse heart,spleen tissue lysates (35ug/lane). PLCZ1 (arrow) was detected using the purified Pab.

Specification

Quantity

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