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CABP1 Antibody (C-term)

AMM05659G Product Datasheet Protocol

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AMM05659G		100 μl / $495

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Leading Biology Inc.

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CABP1 Antibody (C-term)

Brand	Leading Biology	Catalog Number	AMM05659G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CABP1 antibody (C-term).
Molecular Weight	39838 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note=S- CaBP1 is localized at or near the plasma membrane
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	311-343 aa
Target	This CABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-343 amino acids from the C-terminal region of human CABP1.
Isotype	Rabbit Ig
GeneID	9478
UniProt ID	Q9NZU7
Function	Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity).
Summary	CABP1 belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this protein was only detected in retina and brain. Study of the mouse homolog demonstrated that groups of cells expressing this protein are located in the center or inner border of the inner unclear layer of retina.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:10~50
Synonyms	Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1
Images	Western blot analysis of anti-CABP1 Antibody (C-term) (Cat. AMM05659G) in mouse cerebellum tissue lysates (35ug/lane).CABP1(arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human brain tissue reacted with CABP1 antibody (C-term) (Cat. AMM05659G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. CABP1 Antibody (C-term) (Cat. AMM05659G) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CABP1 antibody detected the CABP1 protein (arrow).
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