> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > IPO7 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR16884G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IPO7 antibody (N-term).
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Molecular Weight |
119517 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
142-169 aa
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Target |
This IPO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the N-terminal region of human IPO7.
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Isotype |
Rabbit Ig
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Symbol |
RANBP7
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GeneID |
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UniProt ID |
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Function |
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
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Summary |
The importin-alpha/beta complex and the GTPase Ran mediatenuclear import of proteins with a classical nuclear localizationsignal. The protein encoded by this gene is a member of a class ofapproximately 20 potential Ran targets that share a sequence motifrelated to the Ran-binding site of importin-beta. Similar toimportin-beta, this protein prevents the activation of Ran's GTPaseby RanGAP1 and inhibits nucleotide exchange on RanGTP, and alsobinds directly to nuclear pore complexes where it competes forbinding sites with importin-beta and transportin. This protein hasa Ran-dependent transport cycle and it can cross the nuclearenvelope rapidly and in both directions. At least four importinbeta-like transport receptors, namely importin beta itself,transportin, RanBP5 and RanBP7, directly bind and import ribosomalproteins.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
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Synonyms |
Importin-7, Imp7, Ran-binding protein 7, RanBP7, IPO7, RANBP7
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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