> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > WBSCR22 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR10735G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality WBSCR22 antibody (C-term).
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Molecular Weight |
31880 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Localized diffusely throughout the nucleus and the cytoplasm. Localization is not affected by glucocorticoid treatment
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
253-281 aa
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Target |
This WBSCR22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the C-terminal region of human WBSCR22.
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Isotype |
Rabbit Ig
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Symbol |
MERM1
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GeneID |
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UniProt ID |
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Function |
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (By similarity). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).
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Summary |
This gene encodes a protein containing a nuclearlocalization signal and an S-adenosyl-L-methionine binding motiftypical of methyltransferases, suggesting that the encoded proteinmay act on DNA methylation. This gene is deleted in Williamssyndrome, a multisystem developmental disorder caused by thedeletion of contiguous genes at 7q11.23.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Probable 18S rRNA (guanine-N(7))-methyltransferase, 211-, Bud site selection protein 23 homolog, Metastasis-related methyltransferase 1, Williams-Beuren syndrome chromosomal region 22 protein, WBSCR22, MERM1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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