> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PVR Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM05405G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PVR antibody (C-term).
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Molecular Weight |
45303 Da
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Cellular Localization |
Antigen Cellular Localization:
Isoform Alpha: Cell membrane; Single-pass type I membrane protein Isoform Beta: Secreted.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
314-342 aa
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Target |
This PVR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human PVR.
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Isotype |
Rabbit Ig
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Symbol |
PVS
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GeneID |
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UniProt ID |
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Function |
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
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Summary |
The protein encoded by this gene is a transmembraneglycoprotein belonging to the immunoglobulin superfamily. Theexternal domain mediates cell attachment to the extracellularmatrix molecule vitronectin, while its intracellular domaininteracts with the dynein light chain Tctex-1/DYNLT1. The gene isspecific to the primate lineage, and serves as a cellular receptorfor poliovirus in the first step of poliovirus replication.Multiple transcript variants encoding different isoforms have beenfound for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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