> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > KCNA4 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM06079G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KCNA4 antibody (C-term).
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Molecular Weight |
73257 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
591-619 aa
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Target |
This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
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Isotype |
Rabbit Ig
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Symbol |
KCNA4L
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GeneID |
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UniProt ID |
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Function |
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
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Summary |
Potassium channels represent the most complex class ofvoltage-gated ion channels from both functional and structuralstandpoints. Their diverse functions include regulatingneurotransmitter release, heart rate, insulin secretion, neuronalexcitability, epithelial electrolyte transport, smooth musclecontraction, and cell volume. Four sequence-related potassiumchannel genes - shaker, shaw, shab, and shal - have been identifiedin Drosophila, and each has been shown to have human homolog(s).This gene encodes a member of the potassium channel, voltage-gated,shaker-related subfamily. This member contains sixmembrane-spanning domains with a shaker-type repeat in the fourthsegment. It belongs to the A-type potassium current class, themembers of which may be important in the regulation of the fastrepolarizing phase of action potentials in heart and thus mayinflunce the duration of cardiac action potential. The codingregion of this gene is intronless, and the gene is clustered withgenes KCNA3 and KCNA10 on chromosome 1.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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