> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > LGMN Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR08220G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LGMN antibody (N-term).
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Molecular Weight |
49411 Da
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Cellular Localization |
Antigen Cellular Localization:
Lysosome.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
83-112 aa
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Target |
This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.
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Isotype |
Rabbit Ig
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Symbol |
PRSC1
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GeneID |
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UniProt ID |
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Function |
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
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Summary |
This gene encodes a cysteine protease that has a strictspecificity for hydrolysis of asparaginyl bonds. This enzyme may beinvolved in the processing of bacterial peptides and endogenousproteins for MHC class II presentation in the lysosomal/endosomalsystems. Enzyme activation is triggered by acidic pH and appears tobe autocatalytic. Protein expression occurs after monocytesdifferentiate into dendritic cells. A fully mature, active enzymeis produced following lipopolysaccharide expression in maturedendritic cells. Overexpression of this gene may be associated withthe majority of solid tumor types. This gene has a pseudogene onchromosome 13. Several alternatively spliced transcript variantshave been described, but the biological validity of only two hasbeen determined. These two variants encode the same isoform.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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