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BRAP Antibody(N-term)

Catalog # Availability Size / Price Inquiry
APR15169G 100 μl / $495

BRAP Antibody(N-term)

Brand

Leading Biology

Catalog Number

APR15169G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BRAP antibody(N-term).

Molecular Weight

67305 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

66-95 aa

Target

This BRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human BRAP.

Isotype

Rabbit Ig

Symbol

RNF52

GeneID

UniProt ID

Function

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Summary

The protein encoded by this gene was identified by itsability to bind to the nuclear localization signal of BRCA1 andother proteins. It is a cytoplasmic protein which may regulatenuclear targeting by retaining proteins with a nuclear localizationsignal in the cytoplasm.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Synonyms

BRCA1-associated protein, 632-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52

Images

BRAP Antibody (N-term) (Cat. APR15169G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the BRAP antibody detected the BRAP protein (arrow).

Specification

Quantity

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