> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > AKAP5 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR11366G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AKAP5 antibody (Center).
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Molecular Weight |
47088 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Lipid-anchor. Note=Associates with lipid rafts
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
115-143 aa
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Target |
This AKAP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human AKAP5.
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Isotype |
Rabbit Ig
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Symbol |
AKAP79
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GeneID |
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UniProt ID |
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Function |
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
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Summary |
The A-kinase anchor proteins (AKAPs) are a group ofstructurally diverse proteins, which have the common function ofbinding to the regulatory subunit of protein kinase A (PKA) andconfining the holoenzyme to discrete locations within the cell.This gene encodes a member of the AKAP family. The encoded proteinbinds to the RII-beta regulatory subunit of PKA, and also toprotein kinase C and the phosphatase calcineurin. It ispredominantly expressed in cerebral cortex and may anchor the PKAprotein at postsynaptic densities (PSD) and be involved in theregulation of postsynaptic events. It is also expressed in Tlymphocytes and may function to inhibit interleukin-2 transcriptionby disrupting calcineurin-dependent dephosphorylation of NFAT.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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