> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > FERMT2 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR15947G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FERMT2 antibody (C-term).
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Molecular Weight |
77861 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells Binds to membranes that contain phosphatidylinositides
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
641-669 aa
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Target |
This FERMT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 641-669 amino acids from the C-terminal region of human FERMT2.
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Isotype |
Rabbit Ig
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Symbol |
KIND2, MIG2, PLEKHC1
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GeneID |
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UniProt ID |
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Function |
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
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Summary |
FERMT2 participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Fermitin family homolog 2, Kindlin-2, Mitogen-inducible gene 2 protein, MIG-2, Pleckstrin homology domain-containing family C member 1, PH domain-containing family C member 1, FERMT2, KIND2, MIG2, PLEKHC1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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