> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > DMP1 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR15749G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DMP1 antibody (N-term).
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Molecular Weight |
55782 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
146-175 aa
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Target |
This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
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Summary |
Dentin matrix acidic phosphoprotein is an extracellularmatrix protein and a member of the small integrin binding ligandN-linked glycoprotein family. This protein, which is critical forproper mineralization of bone and dentin, is present in diversecells of bone and tooth tissues. The protein contains a largenumber of acidic domains, multiple phosphorylation sites, afunctional arg-gly-asp cell attachment sequence, and a DNA bindingdomain. In undifferentiated osteoblasts it is primarily a nuclearprotein that regulates the expression of osteoblast-specific genes.During osteoblast maturation the protein becomes phosphorylated andis exported to the extracellular matrix, where it orchestratesmineralized matrix formation. Mutations in the gene are known tocause autosomal recessive hypophosphatemia, a disease thatmanifests as rickets and osteomalacia. The gene structure isconserved in mammals. Two transcript variants encoding differentisoforms have been described for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, DMP1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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