> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > SCRIB Antibody (N-term)Brand |
Leading Biology | Catalog Number |
AMM05408G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SCRIB antibody (N-term).
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Molecular Weight |
174885 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1- dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
382-410 aa
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Target |
This SCRIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 382-410 amino acids from the N-terminal region of human SCRIB.
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Isotype |
Rabbit Ig
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Symbol |
CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
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GeneID |
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UniProt ID |
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Function |
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
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Summary |
SCRIB is a cytoplasmic multimodular scaffold proteintargeted to epithelial adherens junctions and neuronal presynapticcompartments. SCRIB and its orthologs in vertebrates andinvertebrates participate in cell polarization (summary by Nola etal., 2008 [PubMed 18716323]).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Protein scribble homolog, Scribble, hScrib, Protein LAP4, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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