> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > AP3M1 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR14975G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AP3M1 antibody (C-term).
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Molecular Weight |
46939 Da
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Cellular Localization |
Antigen Cellular Localization:
Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
390-418 aa
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Target |
This AP3M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human AP3M1.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
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Summary |
The protein encoded by this gene is the medium subunit ofAP-3, which is an adaptor-related protein complex associated withthe Golgi region as well as more peripheral intracellularstructures. AP-3 facilitates the budding of vesicles from the Golgimembrane and may be directly involved in protein sorting to theendosomal/lysosomal system. AP-3 is a heterotetrameric proteincomplex composed of two large subunits (delta and beta3), a mediumsubunit (mu3), and a small subunit (sigma 3). Mutations in one ofthe large subunits of AP-3 have been associated with theHermansky-Pudlak syndrome, a genetic disorder characterized bydefective lysosome-related organelles. Alternatively splicedtranscript variants encoding the same protein have been observed.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
AP-3 complex subunit mu-1, AP-3 adaptor complex mu3A subunit, Adaptor-related protein complex 3 subunit mu-1, Mu-adaptin 3A, Mu3A-adaptin, AP3M1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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