> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > MAEA Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR17269G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAEA antibody (N-term).
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Molecular Weight |
45287 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled- like pattern
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
16-42 aa
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Target |
This MAEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-42 amino acids from the N-terminal region of human MAEA.
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Isotype |
Rabbit Ig
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Symbol |
EMP
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GeneID |
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UniProt ID |
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Function |
Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
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Summary |
This gene product mediates the attachment of erythroblaststo macrophages. This attachment promotes terminal maturation andenucleation of erythroblasts, presumably by suppressing apoptosis.This protein is an integral membrane protein with the N-terminus onthe extracellular side and the C-terminus on the cytoplasmic sideof the cell. Two immunologically related isoforms of erythroblastmacrophage protein with apparent molecular weights of 33 kD and 36kD were detected in macrophage membranes; this gene encodes thelarger isoform. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been found for this gene, but thebiological validity of some variants has not been determined.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Macrophage erythroblast attacher, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, HLC-10, MAEA, EMP
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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