> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > HMOX2 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR07778G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HMOX2 antibody (N-term).
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Molecular Weight |
36033 Da
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Cellular Localization |
Antigen Cellular Localization:
Microsome. Endoplasmic reticulum.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
24-52 aa
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Target |
This HMOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human HMOX2.
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Isotype |
Rabbit Ig
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Symbol |
HO2
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GeneID |
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UniProt ID |
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Function |
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
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Summary |
Heme oxygenase, an essential enzyme in heme catabolism,cleaves heme to form biliverdin, which is subsequently converted tobilirubin by biliverdin reductase, and carbon monoxide, a putativeneurotransmitter. Heme oxygenase activity is induced by itssubstrate heme and by various nonheme substances. Heme oxygenaseoccurs as 2 isozymes, an inducible heme oxygenase-1 and aconstitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the hemeoxygenase family. Alternative splice variants encoding the sameprotein have been identified at this locus.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Heme oxygenase 2, HO-2, HMOX2, HO2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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