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KLHL2 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR17035G 100 μl / $495

KLHL2 Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR17035G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KLHL2 antibody (N-term).

Molecular Weight

65975 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity)

Host

Rabbit

Species Reactivity

Human

Immunogen

77-103 aa

Target

This KLHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-103 amino acids from the N-terminal region of human KLHL2.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.

Summary

KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Synonyms

Kelch-like protein 2, Actin-binding protein Mayven, KLHL2

Images

KLHL2 Antibody (N-term) (Cat. APR17035G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KLHL2 antibody detected the KLHL2 protein (arrow).

Specification

Quantity

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