> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CDC42EP2 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR15371G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDC42EP2 antibody (C-term).
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Molecular Weight |
22484 Da
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Cellular Localization |
Antigen Cellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
133-160 aa
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Target |
This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.
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Isotype |
Rabbit Ig
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Symbol |
BORG1, CEP2
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GeneID |
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UniProt ID |
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Function |
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
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Summary |
CDC42, a small Rho GTPase, regulates the formation ofF-actin-containing structures through its interaction with thedownstream effector proteins. The protein encoded by this gene is amember of the Borg family of CDC42 effector proteins. Borg familyproteins contain a CRIB (Cdc42/Rac interactive-binding) domain.They bind to, and negatively regulate the function of, CDC42.Coexpression of this protein with dominant negative mutant CDC42protein in fibroblast was found to induce pseudopodia formation,which suggested a role of this protein in actin filament assemblyand cell shape control.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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