> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > MAP3K7IP3 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR17290G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAP3K7IP3 antibody (N-term).
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Molecular Weight |
78683 Da
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
1-30 aa
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Target |
This MAP3K7IP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAP3K7IP3.
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Isotype |
Rabbit Ig
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Symbol |
MAP3K7IP3
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GeneID |
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UniProt ID |
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Function |
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
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Summary |
The product of this gene functions in the NF-kappaB signaltransduction pathway. The encoded protein, and the similar andfunctionally redundant protein MAP3K7IP2/TAB2, forms a ternarycomplex with the protein kinase MAP3K7/TAK1 and either TRAF2 orTRAF6 in response to stimulation with the pro-inflammatorycytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activitytriggers a signaling cascade leading to activation of the NF-kappaBtranscription factor. The human genome contains a relatedpseudogene. Alternatively spliced transcript variants have beendescribed, but their biological validity has not been determined.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3, TAB-3, TGF-beta-activated kinase 1-binding protein 3, TAB3, MAP3K7IP3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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