> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > SEMA6D Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR13256G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SEMA6D antibody (N-term).
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Molecular Weight |
119872 Da
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Cellular Localization |
Antigen Cellular Localization:
Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Single-pass type I membrane protein Isoform 5: Cell membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
19-48 aa
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Target |
This SEMA6D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human SEMA6D.
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Isotype |
Rabbit Ig
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Symbol |
KIAA1479
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GeneID |
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UniProt ID |
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Function |
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
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Summary |
Semaphorins are a large family, including both secretedand membrane associated proteins, many of which have beenimplicated as inhibitors or chemorepellents in axon pathfinding,fasciculation and branching, and target selection. All semaphorinspossess a semaphorin (Sema) domain and a PSI domain (found inplexins, semaphorins and integrins) in the N-terminal extracellularportion. Additional sequence motifs C-terminal to the semaphorindomain allow classification into distinct subfamilies. Resultsdemonstrate that transmembrane semaphorins, like the secreted ones,can act as repulsive axon guidance cues. This gene encodes a class6 vertebrate transmembrane semaphorin that demonstrates alternativesplicing. Several transcript variants have been identified andexpression of the distinct encoded isoforms is thought to beregulated in a tissue- and development-dependent manner. [providedby RefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Semaphorin-6D, SEMA6D, KIAA1479
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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