> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > HMGN3 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR16697G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HMGN3 antibody (N-term).
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Molecular Weight |
10666 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
1-30 aa
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Target |
This HMGN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HMGN3.
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Isotype |
Rabbit Ig
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Symbol |
TRIP7
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GeneID |
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UniProt ID |
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Function |
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
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Summary |
Thyroid hormone receptors are hormone-dependenttranscription factors that regulate expression of a variety ofspecific target genes. The protein encoded by this gene bindsthyroid hormone receptor beta, but only in the presence of thyroidhormone. The encoded protein, a member of the HMGN protein family,is thought to reduce the compactness of the chromatin fiber innucleosomes, thereby enhancing transcription from chromatintemplates. Two transcript variants encoding different isoforms havebeen found for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
High mobility group nucleosome-binding domain-containing protein 3, Thyroid receptor-interacting protein 7, TR-interacting protein 7, TRIP-7, HMGN3, TRIP7
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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