> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > L1CAM Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM06250G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality L1CAM antibody (C-term).
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Molecular Weight |
140003 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
1154-1182 aa
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Target |
This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.
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Isotype |
Rabbit Ig
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Symbol |
CAML1, MIC5
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GeneID |
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UniProt ID |
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Function |
Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.
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Summary |
L1CAM is an axonal glycoproteinbelonging to the immunoglobulin supergene family. The ectodomain,consisting of several immunoglobulin-like domains andfibronectin-like repeats (type III), is linked via a singletransmembrane sequence to a conserved cytoplasmic domain. This celladhesion molecule plays an important role in nervous systemdevelopment, including neuronal migration and differentiation.Mutations in the gene cause three X-linked neurological syndromesknown by the acronym CRASH (corpus callosum hypoplasia,retardation, aphasia, spastic paraplegia and hydrocephalus).Alternative splicing of a neuron-specific exon is thought to befunctionally relevant.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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