> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PRKAR2B Antibody (Center)Brand |
Leading Biology | Catalog Number |
AMM07330G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PRKAR2B antibody (Center).
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Molecular Weight |
46302 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
119-147 aa
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Target |
This PRKAR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-147 amino acids from the Central region of human PRKAR2B.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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Summary |
cAMP is a signaling molecule important for a variety ofcellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase, which transduces the signal throughphosphorylation of different target proteins. The inactive kinaseholoenzyme is a tetramer composed of two regulatory and twocatalytic subunits. cAMP causes the dissociation of the inactiveholoenzyme into a dimer of regulatory subunits bound to four cAMPand two free monomeric catalytic subunits. Four differentregulatory subunits and three catalytic subunits have beenidentified in humans. The protein encoded by this gene is one ofthe regulatory subunits. This subunit can be phosphorylated by theactivated catalytic subunit. This subunit has been shown tointeract with and suppress the transcriptional activity of the cAMPresponsive element binding protein 1 (CREB1) in activated T cells.Knockout studies in mice suggest that this subunit may play animportant role in regulating energy balance and adiposity. Thestudies also suggest that this subunit may mediate the geneinduction and cataleptic behavior induced by haloperidol. [providedby RefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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