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IHH Antibody (N-term)

Catalog # Availability Size / Price Inquiry
APR16814G 100 μl / $495

IHH Antibody (N-term)

Brand

Leading Biology

Catalog Number

APR16814G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IHH antibody (N-term).

Molecular Weight

45251 Da

Cellular Localization

Antigen Cellular Localization: Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface. Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

51-80 aa

Target

This IHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human IHH.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).

Summary

This gene encodes a member of the hedgehog family ofsecreted signaling molecules. Hedgehog proteins are essentialregulators of a variety of developmental processes includinggrowth, patterning and morphogenesis. The encoded proteinspecifically plays a role in bone growth an differentiation.Mutations in this gene are the cause of brachydactyly type A1 whichis characterized by shortening or malformation of the phalanges.Mutations in this gene are also the cause of acrocapitofemoraldysplasia.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Synonyms

Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH

Images

IHH Antibody (N-term) (Cat. APR16814G) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IHH antibody detected the IHH protein (arrow).

IHH Antibody (N-term) (APR16814G)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IHH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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