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PGF Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR09073G 100 μl / $495

PGF Antibody (Center)

Brand

Leading Biology

Catalog Number

APR09073G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PGF antibody (Center).

Molecular Weight

24789 Da

Cellular Localization

Antigen Cellular Localization: Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin

Host

Rabbit

Species Reactivity

Human

Immunogen

120-148 aa

Target

This PGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-148 amino acids from the Central region of human PGF.

Isotype

Rabbit Ig

Symbol

PGFL, PLGF

GeneID

UniProt ID

Function

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

Summary

The PGF gene encodes placenta growth factor, a homolog ofvascular endothelial growth factor (VEGFA; MIM 192240), thatselectively binds to VEGFR1 (FLT1; MIM 165070) and is involved inangiogenesis (Fischer et al., 2007 [PubMed 17981115]; Bais et al.,2010 [PubMed 20371352]).

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Synonyms

Placenta growth factor, PlGF, PGF, PGFL, PLGF

Images

PGF Antibody (Center) (Cat. APR09073G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PGF antibody detected the PGF protein (arrow).

PGF Antibody (Center) (APR09073G)immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PGF Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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