> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ARC Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR11458G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ARC antibody (N-term).
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Molecular Weight |
45316 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton. Endosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:21834987}
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
37-66 aa
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Target |
This ARC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human ARC.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
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Summary |
ARCis required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Activity-regulated cytoskeleton-associated protein, ARC/ARG31, Activity-regulated gene 31 protein homolog, Arg31, ARC {ECO:0000312|EMBL:AAG337051}
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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