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CHRM2 Antibody (Center)

Catalog # Availability Size / Price Inquiry
AMM05767G 100 μl / $495

CHRM2 Antibody (Center)

Brand

Leading Biology

Catalog Number

AMM05767G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CHRM2 antibody (Center).

Molecular Weight

51715 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.

Host

Rabbit

Species Reactivity

Human

Immunogen

336-364 aa

Target

This CHRM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the Central region of human CHRM2.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

Summary

The muscarinic cholinergic receptors belong to a largerfamily of G protein-coupled receptors. The functional diversity ofthese receptors is defined by the binding of acetylcholine to thesereceptors and includes cellular responses such as adenylate cyclaseinhibition, phosphoinositide degeneration, and potassium channelmediation. Muscarinic receptors influence many effects ofacetylcholine in the central and peripheral nervous system. Themuscarinic cholinergic receptor 2 is involved in mediation ofbradycardia and a decrease in cardiac contractility. Multiplealternatively spliced transcript variants have been described forthis gene.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Synonyms

Muscarinic acetylcholine receptor M2, CHRM2

Images

CHRM2 Antibody (Center) (Cat. AMM05767G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CHRM2 antibody detected the CHRM2 protein (arrow).

Western blot analysis of CHRM2 (arrow) using rabbit polyclonal CHRM2 Antibody (Center) (Cat. AMM05767G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CHRM2 gene.

Specification

Quantity

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