> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Mouse Mastl Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR17431G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Mouse Mastl antibody (Center).
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Molecular Weight |
95975 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes
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Host |
Rabbit
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Species Reactivity |
Mouse
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Immunogen |
561-589 aa
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Target |
This Mouse Mastl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the Central region of mouse Mastl.
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Isotype |
Rabbit Ig
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Symbol |
Gw, Gwl
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GeneID |
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UniProt ID |
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Function |
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
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Summary |
Serine/threonine kinase. Mediates mitotic entry and maintenance. Maintains the correct equilibrium between cyclin B1-CDK1 and protein phosphatase 2A (PP2A) by promoting the inactivation of PP2A. Phosphorylates histone protein in vitro. May be involved in megakaryocyte differentiation (By similarity).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, Mastl, Gw, Gwl
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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