> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TIAM2 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
AMM08187G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TIAM2 antibody (N-term).
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Molecular Weight |
190103 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites.
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Host |
Rabbit
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Species Reactivity |
Mouse
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Immunogen |
357-385 aa
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Target |
This TIAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-385 amino acids from the N-terminal region of human TIAM2.
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Isotype |
Rabbit Ig
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Symbol |
KIAA2016, STEF
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GeneID |
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UniProt ID |
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Function |
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
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Summary |
This gene encodes a guanine nucleotide exchange factor. Ahighly similar mouse protein specifically activates ras-related C3botulinum substrate 1, converting this Rho-like guanosinetriphosphatase (GTPase) from a guanosine diphosphate-bound inactivestate to a guanosine triphosphate-bound active state. The encodedprotein may play a role in neural cell development. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2, SIF and TIAM1-like exchange factor, TIAM2, KIAA2016, STEF
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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