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MRAP2 Antibody (Center)

Catalog # Availability Size / Price Inquiry
AMM06462G 100 μl / $495

MRAP2 Antibody (Center)

Brand

Leading Biology

Catalog Number

AMM06462G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MRAP2 antibody (Center).

Molecular Weight

23548 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context

Host

Rabbit

Species Reactivity

Human

Immunogen

58-86 aa

Target

This MRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human MRAP2.

Isotype

Rabbit Ig

Symbol

C6orf117

GeneID

UniProt ID

Function

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

Summary

The specific function of this protein remains unknown.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Synonyms

Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117

Images

MRAP2 Antibody (Center) (Cat. AMM06462G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MRAP2 antibody detected the MRAP2 protein (arrow).

MRAP2 Antibody (Center) (Cat. AMM06462G)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MRAP2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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