> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > KREMEN2 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR17051G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KREMEN2 antibody (Center).
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Molecular Weight |
48849 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
248-276 aa
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Target |
This KREMEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 amino acids from the Central region of human KREMEN2.
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Isotype |
Rabbit Ig
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Symbol |
KRM2
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GeneID |
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UniProt ID |
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Function |
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).
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Summary |
This gene encodes a high-affinity dickkopf homolog 1(DKK1) transmembrane receptor that functionally cooperates withDKK1 to block wingless (WNT)/beta-catenin signaling. The encodedprotein forms a ternary membrane complex with DKK1 and the WNTreceptor lipoprotein receptor-related protein 6 (LRP6), and inducesrapid endocytosis and removal of LRP6 from the plasma membrane. Itcontains extracellular kringle, WSC, and CUB domains. Alternativelyspliced transcript variants encoding distinct isoforms have beenobserved for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Kremen protein 2, Dickkopf receptor 2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose, KREMEN2, KRM2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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