> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ARHGAP22 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR15010G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ARHGAP22 antibody (C-term).
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Molecular Weight |
76779 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity).
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
604-633 aa
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Target |
This ARHGAP22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 604-633 amino acids from the C-terminal region of human ARHGAP22.
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Isotype |
Rabbit Ig
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Symbol |
RHOGAP2
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GeneID |
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UniProt ID |
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Function |
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).
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Summary |
ARHGAPs, such as ARHGAP22, encode negative regulators ofRho GTPases (see ARHA; MIM 165390), which are implicated in actinremodeling, cell polarity, and cell migration (Katoh and Katoh,2004 [PubMed 15254788]).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Rho GTPase-activating protein 22, Rho-type GTPase-activating protein 22, ARHGAP22, RHOGAP2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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