> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TMEM43 Antibody (Center)Brand |
Leading Biology | Catalog Number |
AMM08238G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TMEM43 antibody (Center).
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Molecular Weight |
44876 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B- lamins. The N- and C-termini are oriented towards the nucleoplasm The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity).
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
195-223 aa
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Target |
This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).
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Summary |
This gene belongs to the TMEM43 family. Defects in thisgene are the cause of familial arrhythmogenic right ventriculardysplasia type 5 (ARVD5), also known as arrhythmogenic rightventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic rightventricular dysplasia is an inherited disorder, often involvingboth ventricles, and is characterized by ventricular tachycardia,heart failure, sudden cardiac death, and fibrofatty replacement ofcardiomyocytes. This gene contains a response element for PPARgamma (an adipogenic transcription factor), which may explain thefibrofatty replacement of the myocardium, a characteristicpathological finding in ARVC.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
Transmembrane protein 43, Protein LUMA, TMEM43
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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