> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PC Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR08961G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PC antibody (N-term).
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Molecular Weight |
129634 Da
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Cellular Localization |
Antigen Cellular Localization:
Mitochondrion matrix.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
53-82 aa
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Target |
This PC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human PC.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
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Summary |
This gene encodes pyruvate carboxylase, which requiresbiotin and ATP to catalyse the carboxylation of pyruvate tooxaloacetate. The active enzyme is a homotetramer arranged in atetrahedron which is located exclusively in the mitochondrialmatrix. Pyruvate carboxylase is involved in gluconeogenesis,lipogenesis, insulin secretion and synthesis of theneurotransmitter glutamate. Mutations in this gene have beenassociated with pyruvate carboxylase deficiency. Alternativelyspliced transcript variants with different 5' UTRs, but encodingthe same protein, have been found for this gene. [provided byRefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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