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HIPK1 Antibody (C-term)

APR16693G Product Datasheet Protocol

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APR16693G		100 μl / $495

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Leading Biology Inc.

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HIPK1 Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR16693G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HIPK1 antibody (C-term).
Molecular Weight	130843 Da
Cellular Localization	Antigen Cellular Localization: Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation
Host	Rabbit
Species Reactivity	Human
Immunogen	893-922 aa
Target	This HIPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 893-922 amino acids from the C-terminal region of human HIPK1.
Isotype	Rabbit Ig
Symbol	KIAA0630, MYAK, NBAK2
GeneID	204851
UniProt ID	Q86Z02
Function	Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
Summary	The protein encoded by this gene belongs to the Ser/Thrfamily of protein kinases and HIPK subfamily. It phosphorylateshomeodomain transcription factors and may also function as aco-repressor for homeodomain transcription factors. Alternativesplicing results in four transcript variants encoding four distinctisoforms.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:10~50
Synonyms	Homeodomain-interacting protein kinase 1, Nuclear body-associated kinase 2, HIPK1, KIAA0630, MYAK, NBAK2
Images	Western blot analysis of HIPK1 Antibody (C-term) Pab (Cat. APR16693G) pre-incubated without(lane 1) and with(lane 2) blocking peptide in MCF-7 cell line lysate. HIPK1 Antibody (C-term) (arrow) was detected using the purified Pab. HIPK1 Antibody (C-term) (Cat. APR16693G)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HIPK1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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