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ATP6V1B1 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APG02141G 100 μl / $495

ATP6V1B1 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APG02141G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ATP6V1B1 antibody (C-term).

Molecular Weight

56833 Da

Cellular Localization

Antigen Cellular Localization: Endomembrane system; Peripheral membrane protein. Note=Endomembrane

Host

Rabbit

Species Reactivity

Human

Immunogen

472-501 aa

Target

This ATP6V1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-501 amino acids from the C-terminal region of human ATP6V1B1.

Isotype

Rabbit Ig

Symbol

ATP6B1, VATB, VPP3

GeneID

UniProt ID

Function

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Summary

This gene encodes a component of vacuolar ATPase(V-ATPase), a multisubunit enzyme that mediates acidification ofeukaryotic intracellular organelles. V-ATPase dependent organelleacidification is necessary for such intracellular processes asprotein sorting, zymogen activation, receptor-mediated endocytosis,and synaptic vesicle proton gradient generation. V-ATPase iscomposed of a cytosolic V1 domain and a transmembrane V0 domain.The V1 domain consists of three A and three B subunits, two Gsubunits plus the C, D, E, F, and H subunits. The V1 domaincontains the ATP catalytic site. The V0 domain consists of fivedifferent subunits: a, c, c', c'', and d. Additional isoforms ofmany of the V1 and V0 subunit proteins are encoded by multiplegenes or alternatively spliced transcript variants. This encodedprotein is one of two V1 domain B subunit isoforms and is found inthe kidney. Mutations in this gene cause distal renal tubularacidosis associated with sensorineural deafness. [provided byRefSeq].

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Synonyms

V-type proton ATPase subunit B, kidney isoform, V-ATPase subunit B 1, Endomembrane proton pump 58 kDa subunit, Vacuolar proton pump subunit B 1, ATP6V1B1, ATP6B1, VATB, VPP3

Images

ATP6V1B1 Antibody (C-term) (Cat. APG02141G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ATP6V1B1 antibody detected the ATP6V1B1 protein (arrow).

ATP6V1B1 Antibody (C-term) (Cat. APG02141G)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ATP6V1B1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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