> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > MNDA Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR17401G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MNDA antibody (N-term).
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Molecular Weight |
45836 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
26-53 aa
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Target |
This MNDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of human MNDA.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
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Summary |
The myeloid cell nuclear differentiation antigen (MNDA) isdetected only in nuclei of cells of the granulocyte-monocytelineage. A 200-amino acid region of human MNDA is strikinglysimilar to a region in the proteins encoded by a family ofinterferon-inducible mouse genes, designated Ifi-201, Ifi-202, andIfi-203, that are not regulated in a cell- or tissue-specificfashion. The 1.8-kb MNDA mRNA, which contains aninterferon-stimulated response element in the 5-prime untranslatedregion, was significantly upregulated in human monocytes exposed tointerferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS,CRP, and SPTA1. In its pattern of expression and/or regulation,MNDA resembles IFI16, suggesting that these genes participate inblood cell-specific responses to interferons.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, FC, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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Synonyms |
Myeloid cell nuclear differentiation antigen, MNDA
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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