> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > JUP Antibody (Ascites)Brand |
Leading Biology | Catalog Number |
APR16956G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality JUP antibody (Ascites).
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Molecular Weight |
81745 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
636-663 aa
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Target |
This JUP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 636-663 amino acids from human JUP .
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Clone |
606CT21.5.1
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Isotype |
IgG3
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Symbol |
CTNNG, DP3
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GeneID |
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UniProt ID |
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Function |
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
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Summary |
This gene encodes a major cytoplasmic protein which is theonly known constituent common to submembranous plaques of bothdesmosomes and intermediate junctions. This protein forms distinctcomplexes with cadherins and desmosomal cadherins and is a memberof the catenin family since it contains a distinct repeating aminoacid motif called the armadillo repeat. Mutation in this gene hasbeen associated with Naxos disease. Alternative splicing occurs inthis gene; however, not all transcripts have been fully described.
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Form |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~1600
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Synonyms |
Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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