> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > MC1R Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR08361G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MC1R antibody (Center).
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Molecular Weight |
34706 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Host |
Mouse
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Species Reactivity |
Human
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Immunogen |
205-232 aa
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Target |
This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.
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Clone |
578CT6.2.3
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Isotype |
IgM
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Symbol |
MSHR
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GeneID |
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UniProt ID |
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Function |
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
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Summary |
This intronless gene encodes the receptor protein formelanocyte-stimulating hormone (MSH). The encoded protein, a sevenpass transmembrane G protein coupled receptor, controlsmelanogenesis. Two types of melanin exist: red pheomelanin andblack eumelanin. Gene mutations that lead to a loss in function areassociated with increased pheomelanin production, which leads tolighter skin and hair color. Eumelanin is photoprotective butpheomelanin may contribute to UV-induced skin damage by generatingfree radicals upon UV radiation. Binding of MSH to its receptoractivates the receptor and stimulates eumelanin synthesis. Thisreceptor is a major determining factor in sun sensitivity and is agenetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skinand hair color, providing evidence that this gene is an importantcomponent in determining normal human pigment variation. [providedby RefSeq].
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Form |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:100~250
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Synonyms |
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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