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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NFATC4 / NFAT3 Antibody (internal region)

NFATC4 / NFAT3 Antibody (internal region)

Catalog # Availability Size / Price Inquiry
APR17551G 0.1 mg / $495

NFATC4 / NFAT3 Antibody (internal region)

Brand

Leading Biology

Catalog Number

APR17551G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NFATC4 / NFAT3 antibody (internal region).

Molecular Weight

95449 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription

Host

Goat

Isotype

IgG

Symbol

NFAT3

GeneID

UniProt ID

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

Summary

This antibody is expected to recognize both isoforms (NP_001129494.1; NP_004545.2).

Form

0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

E

Synonyms

Nuclear factor of activated T-cells, cytoplasmic 4, NF-ATc4, NFATc4, T-cell transcription factor NFAT3, NF-AT3, NFATC4, NFAT3

Images

Specification

Quantity

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