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Polyclonal Antibodies >
NFATC4 / NFAT3 Antibody (internal region)Brand |
Leading Biology | Catalog Number |
APR17551G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NFATC4 / NFAT3 antibody (internal region).
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Molecular Weight |
95449 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription
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Host |
Goat
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Isotype |
IgG
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Symbol |
NFAT3
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GeneID |
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UniProt ID |
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Function |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
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Summary |
This antibody is expected to recognize both isoforms (NP_001129494.1; NP_004545.2).
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Form |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
E
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Synonyms |
Nuclear factor of activated T-cells, cytoplasmic 4, NF-ATc4, NFATc4, T-cell transcription factor NFAT3, NF-AT3, NFATC4, NFAT3
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Images |
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Specification |
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Quantity |
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