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MLK2 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR10820G 100 μl / $545

MLK2 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR10820G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MLK2 antibody (C-term).

Molecular Weight

103694 Da

Host

Rabbit

Species Reactivity

Human

Immunogen

628-659 aa

Target

This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 amino acids from the C-terminal region of human MLK2.

Isotype

Rabbit Ig

Symbol

MLK2, MST

GeneID

UniProt ID

Function

Activates the JUN N-terminal pathway.

Summary

MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can bephoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:50~100

Synonyms

Mitogen-activated protein kinase kinase kinase 10, Mixed lineage kinase 2, Protein kinase MST, MAP3K10, MLK2, MST

Images

The anti-MLK2 Pab (Cat. APR10820G) is used in Western blot to detect MLK2 in transfected COS7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX).

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Specification

Quantity

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