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QPCT Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR10915G 100 μl / $545

QPCT Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR10915G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality QPCT antibody (C-term).

Molecular Weight

40877 Da

Cellular Localization

Antigen Cellular Localization: Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

315-343 aa

Target

This QPCT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-343 amino acids from the C-terminal region of human QPCT.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Summary

This gene encodes human pituitary glutaminyl cyclase,which is responsible for the presence of pyroglutamyl residues inmany neuroendocrine peptides. The amino acid sequence of thisenzyme is 86% identical to that of bovine glutaminyl cyclase.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Synonyms

Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, QC, sQC, Glutaminyl-tRNA cyclotransferase, Glutamyl cyclase, EC, QPCT

Images

QPCT Antibody (C-term) (Cat. APR10915G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the QPCT antibody detected the QPCT protein (arrow).

Specification

Quantity

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