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XYLT1 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
AMM08715G 100 μl / $545

XYLT1 Antibody (N-term)

Brand

Leading Biology

Catalog Number

AMM08715G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality XYLT1 antibody (N-term).

Molecular Weight

107569 Da

Cellular Localization

Antigen Cellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein Golgi apparatus membrane; Single- pass type II membrane protein. Secreted. Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted

Host

Rabbit

Species Reactivity

Human

Immunogen

126-155 aa

Target

This XYLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the N-terminal region of human XYLT1.

Isotype

Rabbit Ig

Symbol

XT1

GeneID

UniProt ID

Function

Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.

Summary

This locus encodes a xylosyltransferase enzyme. Theencoded protein catalyzes transfer of UDP-xylose to serine residuesof an acceptor protein substrate. This transfer reaction isnecessary for biosynthesis of glycosaminoglycan chains. Mutationsin this gene have been associated with increased severity ofpseudoxanthoma elasticum.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, FC, E

Dilution

WB~~1:1000 FC~~1:10~50

Synonyms

Xylosyltransferase 1, Peptide O-xylosyltransferase 1, Xylosyltransferase I, XT-I, XylT-I, XYLT1, XT1

Images

XYLT1 Antibody (N-term) (Cat. AMM08715G) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the XYLT1 antibody detected the XYLT1 protein (arrow).

XYLT1 Antibody (N-term) (Cat. AMM08715G) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specification

Quantity

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