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NDUFS8 Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR10895G 100 μl / $545

NDUFS8 Antibody (Center)

Brand

Leading Biology

Catalog Number

APR10895G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NDUFS8 antibody (Center).

Molecular Weight

23705 Da

Cellular Localization

Antigen Cellular Localization: Mitochondrion.

Host

Rabbit

Species Reactivity

Human

Immunogen

81-108 aa

Target

This NDUFS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the Central region of human NDUFS8.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.

Summary

This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Synonyms

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial, Complex I-23kD, CI-23kD, NADH-ubiquinone oxidoreductase 23 kDa subunit, TYKY subunit, NDUFS8

Images

NDUFS8 Antibody (Center) (Cat. APR10895G) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the NDUFS8 antibody detected the NDUFS8 protein (arrow).

NDUFS8 Antibody (Center) (Cat. APR10895G)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NDUFS8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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