> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Plexin-A1 AntibodyBrand |
Leading Biology | Catalog Number |
APR12898G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Plexin-A1 antibody.
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Molecular Weight |
211067 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues in human Plexin-A1 was used as an immunogen.
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Clone |
EPR3449
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Symbol |
NOV, PLXN1
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GeneID |
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UniProt ID |
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Function |
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).
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Summary |
Plexins are large transmembrane receptors for semaphorins. It contains a sema domain and a highly conserved cytoplasmic domain (1). Plexins are classified into four groups: A, B, C, D. Plexin-A1 is a co-receptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A1 plays a role in axon guidance, invasive growth and cell migration. Plexin-A1 modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (2). Plexin-A1 is specific in fetal brain, lung, liver and kidney (3).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:500~1000
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Synonyms |
Plexin-A1, Semaphorin receptor NOV, PLXNA1, NOV, PLXN1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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