> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > GNB2 AntibodyBrand |
Leading Biology | Catalog Number |
AMM04828G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GNB2 antibody.
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Molecular Weight |
37331 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, perinuclear region
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A peptide corresponding to residues near C-term of human GNB2 was used as an immunogen.
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Clone |
EP3262Y
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GeneID |
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UniProt ID |
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Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
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Summary |
Guanine nucleotide binding protein beta-2 (GNB2) is a G-protein subunit belonging to WD repeat G protein beta family. GNB2 functions as a modulator or transducer for trans-membrane signaling pathway systems. G-protein is composed of alpha, beta, and gamma subunits, where beta and gamma subunits are required for GTPase activity and G-protein effector interaction (1). Specifically, GNB2 interacts with the glucocorticoid and migrates into the nucleus to suppress GR-induced trans-activation of the glucocortoid-responsive genes (2). GNB2 has been identified as a binding partner to Ataxin 10, an important target in SCA10 disorder, and also a partner in regulating NTE, a protein known to cause delayed neuropathy with degeneration of nerve axon (3, 4).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:1000~2000
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Synonyms |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, Transducin beta chain 2, GNB2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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