> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Gelsolin AntibodyBrand |
Leading Biology | Catalog Number |
APR16124G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Gelsolin antibody.
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Molecular Weight |
85698 Da
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Cellular Localization |
Antigen Cellular Localization:
Isoform 2: Cytoplasm, cytoskeleton.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues in the C-terminal region of human Gelsolin was used as immunogen.
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Clone |
EP1940Y
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GeneID |
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UniProt ID |
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Function |
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
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Summary |
Gelsolin is a large and complex actin-binding protein that belongs to actin-severing gelsolin/villin super family. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IHC, WB
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Dilution |
IHC~~1:100~250
WB~~1:1000~5000
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Synonyms |
Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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