> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Epsin-1 AntibodyBrand |
Leading Biology | Catalog Number |
APR15855G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Epsin-1 antibody.
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Molecular Weight |
60293 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity)
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
A synthetic peptide corresponding to residues in human Epsin-1 was used as an immunogen
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Clone |
EPR3023
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GeneID |
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UniProt ID |
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Function |
Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
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Summary |
Epsin-1 is a cytosolic adaptor protein and interacting partner for the EH domain-containing region of Eps15. It is involved in the regulation of clathrin-mediated endocytosis via its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15 (1-3). Epsin-1 is a cargo-specific adaptor for influenza virus entry through the clathrin-mediated pathway. In addition to being a clathrin-interacting protiein, Epsin-1 is also an ubiquitin-, and phospholipid-interacting protein (4). It also may function in a signaling pathway connecting the endocytic machinery to the regulation of nuclear function (1).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IF
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Dilution |
WB~~1:5000
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Synonyms |
Epsin-1, EH domain-binding mitotic phosphoprotein, EPS-15-interacting protein 1, EPN1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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