> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > CD72 AntibodyBrand |
Leading Biology | Catalog Number |
APR15354G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD72 antibody.
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Molecular Weight |
40220 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type II membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues in human CD72 was used as an immunogen.
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Clone |
EPR3571
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GeneID |
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UniProt ID |
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Function |
Plays a role in B-cell proliferation and differentiation.
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Summary |
CD72, a type II integral membrane glycopotein and a member of the C-type lectin family of cell surface receptors, is expressed in all stages of B cell development except in terminally differentiated plasma cells (1). Ligation of CD72 enhances B cell growth and differentiation. CD72 transmits positive signals through association with Grb2 and or CD19 and negative signals through association with SHP-1 (2 and 3). CD72 has been reported to bind to CD5, suggesting a role in regulating T-cell activation and proliferation (4). Disregulated expression of CD72 was related to disease such as lupus nephritis (5) and primary Sj鰃ren?s syndrome (6).
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:2000~10000
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Synonyms |
B-cell differentiation antigen CD72, Lyb-2, CD72, CD72
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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