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XKR8 Antibody

Catalog # Availability Size / Price Inquiry
APR06894G 0.1 mg / $695

XKR8 Antibody

Brand

Leading Biology

Catalog Number

APR06894G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality XKR8 Antibody.

Molecular Weight

Predicted: 43 kDa Observed: 47 kDa

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human

Target

XKR8; XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.

Isotype

IgG

Symbol

XRG8

GeneID

UniProt ID

Function

Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.

Summary

The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 μg/ml.

Immunohistochemistry of XKR8 in human stomach tissue with XKR8 antibody at 5 μg/ml.

Immunofluorescence of XKR8 in human stomach tissue with XKR8 antibody at 20 μg/ml.

Specification

Quantity

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